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What is the best drug for hot flashes? A low-dose form of paroxetine (Brisdelle) is the only nonhormone treatment for hot flashes approved by the Food and Drug Administration. Other antidepressants that have been used to treat hot flashes include: Venlafaxine (Effexor XR, Pristiq) Paroxetine (Paxil, Pexeva)
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